Glysolin G Adverse Reactions

The most commonly seen adverse reaction with human insulin therapy include the following: Hypoglycemia: Hypoglycemia is one of the most common adverse effects seen with the use of any type of insulin including human insulin.
The incidence of hypoglycemia in regimens that include Insulin Glargine is significantly reduced compared with regimens containing NPH human insulin. The time of occurrence of hypoglycemia depends on the action profile of the insulin and may, therefore, change when the treatment regimen is changed. While switching from twice daily NPH to once daily Glargine the dose of Glargine should be adjusted to avoid hypoglycemia.
Oedema: Insulin may cause sodium retention and oedema, particularly if previously poor metabolic control is improved by intensified insulin therapy.
Allergy to insulin: Systemic Allergy: Less common, but potentially more serious, is generalized allergy to insulin, which may cause rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse or sweating. Severe cases of generalized allergy may be life threatening.
Local Allergy: Patients occasionally experience redness, swelling and itching at the site of injection of insulin. This condition called local allergy usually clears up in a few days to a few weeks. In some instances, this condition may be related to factors other than insulin, such as irritants in the skin cleansing agent.
Hyperglycemia and ketoacidosis: In patients with insulin-dependent diabetes, prolonged hyperglycemia can result in diabetic acidosis. If uncorrected, prolonged hyperglycemia or diabetic acidosis can result in loss of consciousness or death. Therefore it is important that one should obtain medical assistance immediately.
Injection site reactions: As with any insulin therapy, lipodystrophy may occur at the injection site and delay insulin absorption. Other injection site reactions with insulin therapy include redness, pain, itching, hives, swelling and inflammation. Most minor reactions to insulins usually resolve in a few days to a few weeks.
Insulin resistance: When insulin requirement is increased (>200 IU/day), insulin resistance is said to be developed.
Other: A marked change in glycemic control may cause temporary visual impairment, due to temporary alteration in the turgidity and refractive index of the lens. Intensification of insulin therapy with abrupt improvement in glycemic control may be associated with temporary worsening of diabetic retinopathy.